Formulation Optimization of Extemporaneous Oral Liquids Containing Naloxone and Propranolol for Pediatric Use

There is a need to develop dosage forms suitable for children improve drug treatment. Extemporaneous compounding of drugs one way meet these needs. However, excipients generally considered as safe in adults may not be appropriate intended children. The aim was optimize the composition two pediatric liquid preparations by substituting paraben microbiological preservative and ethanol solubilizer, with more use. oral liquids were Naloxone 1 mg/mL Propranolol 10 mg/mL. Twelve different formulations tested propranolol naloxone, respectively, during screening process select formulations. Sodium benzoate glycerol used pH evaluated. characterized according dispensed dose (dosing accuracy), viscosity osmolality. optimized from amounts sodium assays performed. These shown have satisfactory properties dosing accuracy. results showed that could prepared without addition solubilizer lower osmolality (naloxone), thus reducing risk gastrointestinal side effects.